The basic concept is a good one but the script and cinematography never catch fire, they seem a bit soul-less, a bit like a B movie. The UNISOLs are meant to be cold, not the whole movie.
This movie lacks any significant female role. It had potential for a bit of warmth with the introduction of a non-UNISOL soldier played very well by Mike Pyle, giving Andrei Arlovski‘s latest generation of UNISOL a run for his money. But just as Pyle was growing into his role he got killed off. Interesting plot twist at the very end though, as Pyle’s character appears to have been cloned to create a load of new UNISOLs – this whets the appetite for the fourth & final movie in the saga (Universal Soldier: Day Of Reckoning, 2012) which brings back Van Damme & Arlovski while also co-starring Scott Adkins, but unfortunately does not feature Pyle so the ending to Regeneration is a bit of phony cliffhanger.
Dolph Lundgren does well in his return to the Universal Soldier movie series, as of course does Jean-Claude Van Damme – the main star of every movie in the series except the last (Day Of Reckoning) where Adkins takes over as the main protagonist since Van Damme is getting quite old by this time (in his early 50s) while active soldiers in the real world are generally young (with elastic bodies and impressionable minds). It’s just a shame they’re working with a weak script and deadpan cinematography, so I can’t rate it higher than So-So even if the genre, stars and concept are all excellent.